TWINS AND HEREDITY

Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity.

The Rho/Rho kinase (ROCK) pathway is implicated in experimental hypertension. We, therefore, explored the role of ROCK2 genetic variation in human blood pressure (BP) regulation, exploiting the advantages of a human twin sample to probe heritability. The focus of this work is the common nonsynonymous variant at ROCK2: Thr431Asn. Cardiovascular and autonomic traits displayed substantial heritabi...

Investigating heredity in cutaneous T-cell lymphoma in a unique cohort of Danish twins

Cutaneous T-cell lymphomas (CTCLs) are uncommon but potentially fatal malignancies. The most prevalent clinical forms of CTCL are mycosis fungoides (MF) and the more aggressive leukemic variant, Sézary syndrome (SS). Although the etiology is largely unknown, some lines of evidence indicate that genetic factors and heredity play a role in CTCL. Thus, independent studies reported on strong linkag...

Marriage and Heredity

Mydriasis and heredity.

Routine ophthalmoscopy and fundoscopy of 673 individuals revealed 42 whose irides failed to dilate to a clinically useful degree within 25 to 30 min after the administration of drops of 1% mydracil. These individuals occurred with different frequency among the Aymara, Mestizo, and non-Aymara groups which made up the sample of examinees. The phenomenon was most common among the Aymara, less comm...

Heredity and Mental Diseases

Lecture, on heredity in relation to mental disease and mental deficiency by Sir Frederick Mott, and also the obituary notice of the distinguished author. The lecture is an important contribution to the problem of insanity and mental deficiency. Sir Frederick opened his lecture by asking whether the increase in the number of registered cases of insanity is due to a raising of the standard of men...